The scientific scope of i-bio focuses on elucidating metabolic physiology, genetic regulation, and nutrient & environment signalling in the budding yeast Saccharomyces cerevisiae, under industry-relevant conditions. The engineering scope of i-bio focuses on translating fundamental biological knowledge into standardised genetic engineering parts for industrial application. Research areas of i-bio include: metabolic physiology & genetics, metabolic engineering, synthetic biology, and bioprocess engineering in yeast.
Highly efficient xylose-fermenting S. cerevisiae
Highly efficient terpene-producing yeast platform
Characterisation of yeast promoters
Industrial synthetic biological tools (on-going)
Assemble large plasmid DNA
Genetic modification in S. cerevisiae
Metabolite analysis (sugars, organic acids, alcohols, lipids, aromatic compounds, etc.)Enquiry
Metabolic modules include xylose-utilizating pathway modules, non-oxidative phosphate pathway modules, mevalonate pathway modules, specific terpene-producing modules (limonene, linalool, trans-nerolidol, lycopene).
Regulatory modules include promoter pools, N-end pathway protein degradation modules, C-terminal protein degradation modules, ER-membrane targetting tools; more are coming.Read More